Ruxotor 5 mg

Description

🟩 Ruxotor 5 mg

Generic Name: Ruxolitinib Phosphate INN
Brand Name: Ruxotor
Manufacturer: Everest Pharmaceuticals Ltd.
Strength & Form: 5 mg | Film-coated tablets
Pack Size: 60 tablets

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📌 Indications:

Ruxotor (Ruxolitinib) is prescribed for:

• Myelofibrosis (MF): including primary MF, post–polycythemia vera MF, and post–essential thrombocythemia MF.

• Polycythemia Vera (PV): in adult patients resistant or intolerant to hydroxyurea.

• Graft-versus-Host Disease (GVHD): treatment of steroid-refractory acute and chronic GVHD.

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💊 Pharmacology:

• Ruxolitinib is a potent Janus-associated kinase (JAK1 & JAK2) inhibitor.

• Overactive JAK-STAT signaling contributes to abnormal blood cell production, inflammation, and immune dysfunction.

• By blocking this pathway, Ruxotor helps reduce splenomegaly, control blood counts, alleviate disease-related symptoms, and improve overall survival in patients with MF and PV.

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💉 Dosage & Administration:

• Myelofibrosis/Polycythemia Vera: Initial dose is individualized based on platelet count (generally 5–20 mg twice daily).

• GVHD: 5 mg twice daily, with dose adjustment according to tolerance.

• Tablets should be swallowed whole with water, with or without food.

• Dose modifications are necessary in case of low blood counts or adverse effects.

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⚠️ Precautions & Warnings:

• Monitor for anemia, thrombocytopenia, and neutropenia.

• Risk of serious infections (TB, herpes zoster, hepatitis B reactivation).

• Long-term use may increase the risk of non-melanoma skin cancers.

• Regular complete blood count (CBC) monitoring is essential.

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❌ Contraindications:

• Hypersensitivity to Ruxolitinib or formulation components.

• Severe organ dysfunction without close monitoring.

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🤰 Pregnancy & Lactation:

• May cause fetal harm; avoid during pregnancy.

• Breastfeeding is not recommended while on therapy.

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⚕️ Side Effects:

Common:

• Anemia, thrombocytopenia, neutropenia

• Dizziness, headache

• Easy bruising

• Weight gain

Serious:

• Severe infections

• Progressive multifocal leukoencephalopathy (PML)

• Secondary malignancies

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🧊 Storage Conditions:

• Store below 30°C, in a cool and dry place.

• Protect from light and moisture.

• Keep out of reach of children.