Orfoxen 0.8 mg (Orforglipron INN) – Everest Pharmaceuticals Ltd.

Oral GLP-1 Receptor Agonist for Type 2 Diabetes and Weight Management

📌 Indications:

Orfoxen 0.8 mg is indicated as an adjunct to diet and exercise for:

• Type 2 Diabetes Mellitus
• Improvement of glycemic control in adults
• Weight management in overweight or obese patients (as clinically appropriate)

💊 Pharmacology:

Orforglipron is a non-peptide GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and promotes satiety. These actions contribute to improved blood glucose control and clinically meaningful weight loss.

💉 Dosage & Administration:

• Administer orally once daily, with or without food.
• Dose titration should be individualized based on patient response and tolerability.
• Follow the prescribing physician's recommendations.
• Continue treatment along with appropriate dietary and lifestyle modifications.

⚠️ Precautions & Warnings:

• Monitor blood glucose levels regularly.
• Use with caution in patients with a history of pancreatitis.
• Gastrointestinal adverse effects may occur, especially during dose escalation.
• Risk of hypoglycemia may increase when combined with insulin or sulfonylureas.
• Patients with severe gastrointestinal disease should be monitored carefully.

❌ Contraindications:

• Hypersensitivity to Orforglipron or any component of the formulation.
• Patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), if applicable according to local prescribing information.

🤰 Pregnancy & Lactation:

• Use during pregnancy only if clearly needed.
• Breastfeeding is not recommended during treatment.
• Women of childbearing potential should consult their physician before use.

⚕️ Side Effects:

Common adverse effects include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal discomfort
• Decreased appetite

Serious but uncommon adverse effects may include:

• Pancreatitis
• Severe gastrointestinal reactions
• Hypoglycemia (when used with insulin or sulfonylureas)

🧊 Storage Conditions:

• Store below 30°C in a cool and dry place.
• Protect from excessive heat, moisture, and direct sunlight.
• Keep out of reach of children.