🟩 Ruxotor 5 mg
Generic Name: Ruxolitinib Phosphate INN
Brand Name: Ruxotor
Manufacturer: Everest Pharmaceuticals Ltd.
Strength & Form: 5 mg | Film-coated tablets
Pack Size: 60 tablets
📌 Indications:
Ruxotor (Ruxolitinib) is prescribed for:
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Myelofibrosis (MF): including primary MF, post–polycythemia vera MF, and post–essential thrombocythemia MF.
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Polycythemia Vera (PV): in adult patients resistant or intolerant to hydroxyurea.
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Graft-versus-Host Disease (GVHD): treatment of steroid-refractory acute and chronic GVHD.
💊 Pharmacology:
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Ruxolitinib is a potent Janus-associated kinase (JAK1 & JAK2) inhibitor.
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Overactive JAK-STAT signaling contributes to abnormal blood cell production, inflammation, and immune dysfunction.
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By blocking this pathway, Ruxotor helps reduce splenomegaly, control blood counts, alleviate disease-related symptoms, and improve overall survival in patients with MF and PV.
💉 Dosage & Administration:
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Myelofibrosis/Polycythemia Vera: Initial dose is individualized based on platelet count (generally 5–20 mg twice daily).
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GVHD: 5 mg twice daily, with dose adjustment according to tolerance.
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Tablets should be swallowed whole with water, with or without food.
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Dose modifications are necessary in case of low blood counts or adverse effects.
⚠️ Precautions & Warnings:
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Monitor for anemia, thrombocytopenia, and neutropenia.
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Risk of serious infections (TB, herpes zoster, hepatitis B reactivation).
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Long-term use may increase the risk of non-melanoma skin cancers.
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Regular complete blood count (CBC) monitoring is essential.
❌ Contraindications:
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Hypersensitivity to Ruxolitinib or formulation components.
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Severe organ dysfunction without close monitoring.
🤰 Pregnancy & Lactation:
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May cause fetal harm; avoid during pregnancy.
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Breastfeeding is not recommended while on therapy.
⚕️ Side Effects:
Common:
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Anemia, thrombocytopenia, neutropenia
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Dizziness, headache
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Easy bruising
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Weight gain
Serious:
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Severe infections
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Progressive multifocal leukoencephalopathy (PML)
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Secondary malignancies
🧊 Storage Conditions:
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Store below 30°C, in a cool and dry place.
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Protect from light and moisture.
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Keep out of reach of children.
