Ruxotor 10 mg

Description

🟩 Ruxotor 10 mg

Generic Name: Ruxolitinib Phosphate INN
Brand Name: Ruxotor
Manufacturer: Everest Pharmaceuticals Ltd.
Strength & Form: 10 mg | Film-coated tablets
Pack Size: 60 tablets

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📌 Indications:

Ruxotor (Ruxolitinib) is indicated for the treatment of:

• Myelofibrosis (MF): including primary myelofibrosis, post–polycythemia vera MF, and post–essential thrombocythemia MF.

• Polycythemia Vera (PV): in patients resistant or intolerant to hydroxyurea.

• Graft-versus-Host Disease (GVHD): in steroid-refractory acute and chronic GVHD.

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💊 Pharmacology:

• Ruxolitinib is a Janus-associated kinase (JAK1 and JAK2) inhibitor.

• It works by reducing overactive JAK-STAT signaling, which is involved in abnormal blood cell production, inflammation, and immune system dysregulation.

• By inhibiting JAK1/JAK2, Ruxotor decreases splenomegaly, alleviates disease-related symptoms (fever, night sweats, weight loss), and improves quality of life in MF and PV patients.

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💉 Dosage & Administration:

• Typical starting dose (MF/PV): 5–20 mg orally twice daily, based on platelet count.

• GVHD: 5–10 mg twice daily (dose adjustments may be needed).

• Doses should be individualized according to platelet counts, hemoglobin levels, and neutrophil counts.

• Tablets should be swallowed whole, with or without food.

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⚠️ Precautions & Warnings:

• Monitor for cytopenias (anemia, thrombocytopenia, neutropenia).

• Risk of serious infections (TB, herpes zoster, hepatitis B reactivation).

• May increase the risk of skin cancers and non-melanoma malignancies.

• Regular monitoring of complete blood counts (CBC) is essential.

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❌ Contraindications:

• Hypersensitivity to Ruxolitinib or formulation components.

• Severe hepatic impairment (without close monitoring and dose adjustment).

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🤰 Pregnancy & Lactation:

• May cause fetal harm; avoid during pregnancy.

• Breastfeeding is not recommended during treatment.

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⚕️ Side Effects:

Common:

• Anemia, thrombocytopenia, neutropenia

• Headache, dizziness

• Bruising

• Increased liver enzymes

• Weight gain

Serious:

• Severe infections

• Progressive multifocal leukoencephalopathy (PML)

• Secondary malignancies

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🧊 Storage Conditions:

• Store below 30°C, in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.